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Build Models...

Generate 3D structural models for the selected entries.

This option automatically detects the construct format of each selected candidate and utilizes the ImmuneBuilder deep learning suite:

  • ABodyBuilder2 for standard antibody Fv pairs (heavy and light variable domains).

  • NanoBodyBuilder2 for single-domain VHH (nanobody) entries.

  • TCRBuilder2 for T-cell receptor (TCR) pairs (\(\alpha\) and \(\beta\) variable domains).

This process calculates the variable domain structure and automatically updates the entry with its corresponding structural surface properties (e.g., SPH, SPP, SPN, SPCD).

[!NOTE] This builds only the variable domain models, which might not give completely accurate surface properties since residues that would normally be buried by the CL/CH domains in a Fab structure will be exposed to solvent in the Fv model.

[!IMPORTANT] Verify the structure models external to AbLead before relying on their validity! Use the Structure Models interface to download and inspect the models.