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Release Notes

2026-06-08

  • Integrated Residue-Level Covariance Violations (CVV): Embedded residue-level covariance highlights directly in the Liabilities dashboard and export tools, introducing unified filtering and coloring matching the Covariance Analysis workspace.
  • Enhanced Covariance Workspace Layout: Added a collapsible settings sidebar for maximizing screen real estate, aligned grid row styling with the PFA track layout, and introduced automated mutation details loading and real-time indicator refreshes when editing sequences.
  • LaTeX Math Rendering in Help Docs: Enabled native browser-side LaTeX rendering via MathJax across all system help documentation, providing high-fidelity mathematical equations and threshold formulas.
  • Refined Table Alignment and Grid Scaling: Optimized cell spacing, consensus highlights, and text sizing between the PFA and Covariance alignment grids to ensure a unified visual design.

2026-06-07

  • AJAX Inline User Expirations: Added support for inline expiration dates editing with real-time automatic user deactivations inside the administration dashboard.
  • Empirical Validation Documentation: Added comprehensive developability drop-off threshold reports and correlation scatter plots based on clinical Jain dataset statistics.
  • Closest Human Germline in Covariance: Integrated closest human germlines mapping to correctly evaluate covariance partner constraints for non-human sequence targets.

2026-06-06

  • Region and Vernier Columns in Covariance: Appended region labels and classic Vernier zone markers to active covariance violations summaries.
  • Grid and Violations Row Sync: Implemented interactive selection highlighting and scrolling synchronization between alignment grid columns and summary violation rows.
  • Closest Germline Row in PFA and Covariance: Embedded closest human germline sequence tracks with fading match styling directly beneath query residues.

2026-06-05

  • OMES Sum Severity Grading: Aligned covariance severity metrics to be evaluated by cumulative partner OMES scores instead of raw counts.
  • Multi-Severity Toggling controls: Added additive select/deselect settings buttons for Low, Medium, and Severe covariance violations.
  • Optimized Covariance Databases: Re-ran the database pipelines using a streaming gzipped sequence reader and early-termination controls to create uniform reference models.

2026-06-04

  • Sandbox Mutation Panel Updates: Implemented sandbox edit sequences with dynamic "Repaired" vs. "New" violation statuses, custom alert modals, and precise OMES threshold overrides.
  • AbLang/IgBert Grid Integrations: Corrected API data matching paths to restore language model grids in the Covariance workspace.

2026-06-03

  • Three-Way Grid Column Sorting: Added Ascending / Descending / Default sort cycles across results dashboards, user management tables, and engineering grids.
  • Refined Residue Indicators: Standardized high-contrast eggshell (mutations) and orange (observations) markers with black outlines across workspaces.
  • PDB Files sorting and filtering: Implemented popover search filters and sequence sorting inside the PDB database manager.

2026-06-02

  • Fv Only Mutation Grid Toggle: Added a filter toggle to evaluate only variable domain sequences, excluding leader and constant regions.
  • Molstar 3D Viewer in pI Combinations: Integrated PDBe Molstar structure alignments to visually map target surface mutants and combination designs.
  • Auto-Saving Fv Limits: Swapped manual admin buttons with immediate inline AJAX auto-saving for user build allowances.

2026-06-01

  • Optimized Humanization & Repair Queueing: Upgraded backend queues to target only newly created construct records during bulk humanization or repairs, saving computing resources.
  • Honegger & VHH Humanization Legend Options: Visual overlays and selection tags representing Honegger and VHH residues within humanization alignments.

2026-05-31

  • Refined Exclusions interface: Redesigned humanization exclusions panel with mutually exclusive radio selectors and inline custom CDR definition rules.

2026-05-30

  • Account Expiration Boundaries: Implemented administrator-controlled user account expiration dates, including warning notices, login popups, and automatic access lockouts.

2026-05-29

  • Molstar 3D Structure Viewer in Engineering: Pinned interactive PDBe Molstar structure viewers dynamically color-coded by region into the Engineering and pI workspaces.
  • High-Severity Liabilities Shortcuts: Added a "Select Severe" settings button to instantly highlight candidates with high-risk liabilities.

2026-05-28

  • Alpaca Germline Matching: Added VICUGNA PACOS germline V and JH matching database supports.
  • Engineering Grids Column Sorting: Upgraded Variant Designs tables with interactive column sorting and bold header formatting.

2026-05-27

  • Multi-Row Liabilities Selection: Interactive row highlighting carrying synchronized PDBe Molstar spacefill overlays.
  • Dynamic Constant Domain Repair: Dynamic VL/CL split-codon junction warnings and automated insertion/deletion repair controls.

2026-05-26

  • PFA Germline Fallback: Smart fallback mapping to closest reference human germlines when primary determined candidates lack database frequency scores.
  • Surgical Workspace Grid Refreshes: Replaced full-page reloads with targeted iframe updates when saving structural models and mutation designs.

2026-05-25

  • Bulk Notes Edit: Inline menu options to batch append or overwrite notes for selected sequences.
  • Recalibrated IgBert Scoring: Concatenated heavy/light sequences to utilize IgBert paired-attention inference with updated warning thresholds.

2026-05-24

  • VHH 3D Modeling Support: Integrated NanoBodyBuilder2 to automatically build heavy-chain-only nanobody models.
  • Surface Mutagenesis Workspace: Restored the surface residue editor displaying sidechain SASA levels alongside custom representation styling.

2026-05-23

  • Model-Specific Cutoffs in Liabilities: Replaced unified cutoffs with independent sliders for AbLang, AbLang2, and IgBert thresholds.
  • Impersonate User Option: Added administrative impersonation toggles within the User Management dashboard.

2026-05-22

  • IgBert Paired Scoring: Added paired-chain stability profiling across workspaces, Clinical Comparison modules, and exports.
  • CSP Build Button Compliance: Refactored inline JS button handlers to programmatic event listeners to satisfy Content Security Policies.

2026-05-21

  • Analytics & Consent Management: Integrated Cookie Consent Banners and Google Analytics 4 tracking.
  • Account Deletion Safeguards: Database cascade deletion protections to prevent administrator lockouts.

2026-05-20

  • Passkeys (WebAuthn): Biometric and hardware security key sign-ins from user profiles.
  • Bulk User Import: CSV administrative uploads with temporary hyphenated word passphrase assignments.

2026-05-19

  • Multispecific FASTA Imports: Automatic grouping of multispecific antibodies.
  • Fv Pair Extraction Utility: Segment variable domains from multispecific IgG candidates for developability scoring.

2026-05-18

  • Multispecific Assembler Workspace: Drag-and-drop peptide linkers, Knobs-into-Holes (KiH) domains, and CrossMab crossover parts.

2026-05-13

  • Germline Performance Caching: Cached database lookup indexes to reduce page loading delays.

2026-05-12

  • Molstar in PDB Manager: Added structural overlays directly inside the PDB Files manager dashboard.
  • Multi-Species Germline Targets: Integrated Human, Mouse, Rat, Rabbit, and Rhesus databases.

2026-05-11

  • Allotype Detection: Automatic constant domain allotype annotation.
  • Germline Engineering Mutator: Selection modal and indicator dots integration within the Germline view.

2026-05-10

  • Automated Fv 3D Modeling: Batch structural modeling utilizing ABodyBuilder2.
  • Germline Analysis view: Split V and J germline identity and mapping views.